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New publication: Yuan M#, Ngou BPM#, Ding P*, Xin XF*. PTI-ETI crosstalk: an integrative view of plant immunity. Curr Opin Plant Biol. 2021 Mar 5;62:102030.

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Invited review: PTI-ETI crosstalk: an integrative view of plant immunity

Plants resist attacks by pathogens via innate immune responses, which are initiated by cell surface-localized pattern-recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) leading to pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively. Although the two classes of immune receptors involve different activation mechanisms and appear to require different early signalling components, PTI and ETI eventually converge into many similar downstream responses, albeit with distinct amplitudes and dynamics. Increasing evidence suggests the existence of intricate interactions between PRR-mediated and NLR-mediated signalling cascades as well as common signalling components shared by both. Future investigation of the mechanisms underlying signal collaboration between PRR-initiated and NLR-initiated immunity will enable a more complete understanding of the plant immune system. This review discusses recent advances in our understanding of the relationship between the two layers of plant innate immunity.


This review article has been published online in Current Opinion in Plant Biology on March 5, 2021 (https://doi.org/10.1016/j.pbi.2021.102030).

Fig 1. (a)PRR and NLR signalling co-regulate immune responses and converge at multiple points. (b) Dynamics and amplitudes of immune responses under different conditions (i.e. PTI alone, ETI alone, or PTI + ETI).

Fig 2. An updated model of the plant immune system.

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